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Reporting Summary Further information on research design is available in the Nature Research Reporting Summary linked to this article

Other cortical regions strongly activated were the mid-insula, the amygdala, and the (dorsal) anterior cingulate gyrus

Smugglers are filling the gap while legitimate businesses suffer. Panelists on the podcast said illegal cigarette manufacturers are exploiting the system by avoiding the Federal Excise Duty and producing below the legal price threshold

The industry is notorious for their targeted marketing towards these communities, and it is yet to be seen whether they will follow down the same path for IQOS and the mentholated HeatSticks